Hydrogen Bromide → HCID 25255742, compound

Participants

Reaction Conditions

Reaction Steps

300 mg ethyl 4-[4-[(2R)-3-[4-amino-3-chloro-5-(trifluoromethyl)phenyl]-1-oxo-2-[[[4-(1,2,4,5-tetrahydro-2-oxo-3H-1,3-benzodiazepin-3-yl)-1-piperidinyl]carbonyl]oxy]propyl]-1-piperazinyl]-piperidine-1-acetate (0.379 mmol) of are dissolved in 3 ml isopropanol at ambient temperature and combined with 75.4 μL hydrobromic acid (30% in glacial acetic acid, 0.379 mmol), whereupon a sticky precipitate is immediately formed. The suspension is heated to 100° C., whereupon the precipitate formed goes back into solution. The solution is slowly cooled to ambient temperature. The solid formed is filtered off, washed with a little isopropanol and dried for 12 hours at 40° C.

Provenance & Evidence