2-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonyl chloride → HCID 44547840, compound

HRID 1038408Notes

Reaction equation

HRID 1038408 reaction equation
[NH2:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH:11]3[C:16]([C:17]#[N:18])=[C:15]([CH3:19])[NH:14][C:13]([CH3:20])=[C:12]3[C:21]#[N:22])[CH:9]=2)[N:4](C(OC(C)(C)C)=O)[N:3]=1.[O:30]=[C:31]1[CH2:35][CH2:34][C:33](=[O:36])[N:32]1[CH2:37][CH2:38][S:39](Cl)(=[O:41])=[O:40]>>[C:21]([C:12]1[CH:11]([C:8]2[CH:9]=[C:10]3[C:5](=[CH:6][CH:7]=2)[NH:4][N:3]=[C:2]3[NH:1][S:39]([CH2:38][CH2:37][N:32]2[C:33](=[O:36])[CH2:34][CH2:35][C:31]2=[O:30])(=[O:40])=[O:41])[C:16]([C:17]#[N:18])=[C:15]([CH3:19])[NH:14][C:13]=1[CH3:20])#[N:22]

Participants

3

Reactant 2

HCID 185240132-(2,5-Dioxo-pyrrolidin-1-yl)-ethanesulfonyl chlorideHCID 24959832tert-Butyl 3-amino-5-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)-1H-indazole-1-carboxylate

Product 1

HCID 44547840HCID 44547840, compound

Procedure

The title compound was prepared following the procedure described for Example 1 using 100 mg (0.256 mmol) tert-butyl 3-amino-5-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)-1H-indazole-1-carboxylate (Example 3A) and 173 mg (0.77 mmol) 2-(2,5-dioxopyrrolidin-1-yl)ethane-sulfonyl chloride. Yield: 20 mg (17% of th.).

Sources & evidence

ORD record
ord-41afefe52987475c9b57e4c86d114de5
Source dataset
uspto-grants-2013_10
Patent number
US08551989B2

Reaction notes

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