Trifluoroacetic acid → HCID 67354964, compound

Participants

Reaction Steps

120 mg (0.19 mmol) tert-butyl 3-{bis[(2-methylpropyl)sulfonyl]amino}-5-(3,5-dicyano-2,6-dimethyl-1,4-dihydropyridin-4-yl)-1H-indazole-1-carboxylate (Example 18A) were dissolved in dichloromethane (4 ml) and treated with 0.161 ml (2.1 mmol) trifluoroacetic acid. The mixture was stirred at room temperature for 2 h and then concentrated under reduced pressure. The residue was dissolved in ethyl acetate and washed with saturated aqueous sodium bicarbonate solution. The organic layer was separated, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The residue was dissolved in 1,4-dioxane (4 ml), treated with 1 M aqueous lithium hydroxide solution (0.75 ml) and stirred at room temperature for 4 h. The mixture was then concentrated under reduced pressure, and the residue was purified by preparative RP-HPLC (acetonitrile/water gradient) to give 13 mg (16% of th.) of the title compound.

Provenance & Evidence