Acetonitrile → HCID 24961123, compound

Participants

Reaction Steps

A mixture of Example 10 (78 mg, 0.174 mmol), 23a (48 mg, 0.348 mmol), K2CO3 (120 mg, 0.870 mmol) and KI (32 mg, 0.191 mmol) in CH3CN (10 mL) was reacted under microwave condition at 160° C. for 2 h. After the reaction was complete, the mixture was filtered and evaporated. The residue was purified by column chromatography (EA:MeOH=10:1) to afford the title compound (44 mg, 44.4% yield) as solid. 1H-NMR (300 MHz, CDCl3): δ=8.14-8.15 (d, 1H), 7.62-7.63 (d, 1H), 7.59 (s, 1H), 7.28-7.33 (m, 1H), 6.95-7.06 (dd, 1H), 6.94-6.95 (d, 1H), 6.01-6.03 (m, 1H), 4.02 (m, 1H), 3.59-3.63 (t, 2H), 3.37 (s, 3H), 3.18-3.22 (m, 2H), 2.71-2.75 (t, 2H), 2.56 (s, 3H), 2.00-2.43 (m, 6H), 1.84-1.86 (d, 3H). LC/MS [M+H]+: 507.2.

Provenance & Evidence