Thionyl Chloride → 5-Bromothiophene-2-carbonyl chloride

Participants

Reaction Steps

A mixture of 5-bromothiophene-2-carboxylic acid (300 mg 1.45 mmol), thionyl chloride (423 μL, 5.80 mmol), and N,N-dimethylformamide (1 drop) was dissolved in chloroform (3 mL), and refluxed for 1 hour. After cooling down, the reaction mixture was concentrated under reduced pressure to give the titled reference compound (324 mg) as a pale yellow solid. (Yield 99%)

Provenance & Evidence