Water → 2-(4-{5-[1,1,1,3,3,3-Hexafluoro-2-(4-methoxybenzyloxy)propan-2-yl]-4-propylpyridin-2-yl}piperazin-1-yl)ethyl acetate

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Reaction Steps

2-{4-[5-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)-4-propylpyridin-2-yl]piperazin-1-yl}ethyl acetate (211 mg, 0.461 mol) was dissolved in N,N′-dimethylformamide (2.3 mL), and added potassium carbonate (191 mg, 1.38 mmol) at room temperature. Under ice-cold conditions, methoxybenzyl chloride (125 μL, 0.923 mmol) was added, and the mixture was stirred at room temperature overnight. Subsequently, potassium carbonate (96 mg, 0.690 mmol) was further added at room temperature, methoxybenzyl chloride (63 μL, 0.462 mmol) was added under ice-cold conditions, and the mixture was stirred at room temperature for 8 hours. The reaction solution was added water, extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The title compound (479 mg) was obtained as a red-brown oil.

Provenance & Evidence