反应详情

温度

70 °C

1-[4-(1-Methylethoxy)phenyl]ethanone (35.2 g, 196 mmol) was dissolved in ethanol (200 mL) and water (200 mL), added sodium cyanide (14.4 g, 294 mmol) and ammonium carbonate (226 g, 9.41 mol), and the mixture was stirred at 70° C. for 13 hours. The reaction solution was filtered, washed with water and hexane/ethyl acetate, and dried. The title compound (35.1 g (yield 72%)) was obtained as a white crystal.

1. filtrationThe reaction solution was filtered
2. washwashed with water and hexane/ethyl acetate
3. customdried