Hydrochloric Acid → HCID 66598328, compound

Participants

Reaction Conditions

Reaction Steps

Methyl (Z)-4-{4-[2-(benzyloxy)ethyl]piperazin-1-yl}-3-(prop-1-en-1-yl)benzoate (20 mg, 0.0507 mmol) was dissolved in methanol (1.0 mL). Under ice-cold conditions, 4N aqueous solution of sodium hydroxide (50 μL) was added and stirred at 50° C. overnight. The reaction solution was added 4N aqueous solution of hydrochloric acid under ice-cold conditions, and extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (hexane/acetone). The title compound (13 mg (yield 65%)) was obtained as a yellow oil.

Provenance & Evidence