反应详情

(Z)-1-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}piperazine (38 mg, 0.0595 mmol) was dissolved in dichloromethane (1.0 mL). Under ice-cold conditions, N,N′-dimethylaniline (9.0 μL, 0.0714 mmol) and bromoacetylbromide (5.5 μL, 0.0625 mmol) were added, and the mixture was stirred under ice-cold conditions for 0.5 hours. Then, under ice-cold conditions, N,N′-dimethylaniline (9.0 μL, 0.0714 mmol) and bromoacetylbromide (5.5 μL, 0.0625 mmol) were added, and the mixture was stirred under ice-cold conditions for 0.5 hours. The reaction solution was concentrated in vacuo, and the obtained residue was purified by silica-gel column chromatography (hexane/acetone). The title compound (16 mg (yield 47%)) was obtained as a yellow oil.

1. stirringthe mixture was stirred under ice-cold conditions for 0.5 hours
2. concentrationThe reaction solution was concentrated in vacuo
3. customthe obtained residue was purified by silica-gel column chromatography (hexane/acetone)