反应详情

温度

140 °C

5-(1-methylethoxy)-2-methylpyridine 1-oxide (234 mg, 1.40 mmol) was dissolved in acetic anhydride (3.0 mL), and the mixture was stirred at 140° C. for 1 hour. At room temperature, the reaction solution was added methanol, stirred, concentrated in vacuo, and extracted with ethyl acetate. The organic layer was washed with an aqueous solution of sodium hydrogen carbonate and brine, dried over sodium sulfate, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (hexane/ethyl acetate) and [5-(1-methylethoxy)pyridin-2-yl]methyl acetate (209 mg (yield 71%)) was obtained as a yellow oil.

1. stirringstirred
2. concentrationconcentrated in vacuo
3. extractionextracted with ethyl acetate
4. washThe organic layer was washed with an aqueous solution of sodium hydrogen carbonate and brine
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo
7. customThe obtained residue was purified by silica-gel column chromatography (hexane/ethyl acetate)