Hydrochloric Acid → HCID 66598276, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-[6-(methoxycarbonyl)-4-propylpyridin-3-yl]piperazine-1-carboxylate (111 mg, 0.307 mmol) in methanol (3.0 mL), 4N aqueous solution of sodium hydroxide (383 μL, 1.53 mmol) was added under ice-cold conditions, and the mixture was stirred at room temperature overnight. The reaction solution was added 4N aqueous solution of hydrochloric acid under ice-cold conditions, and extracted with chloroform. The organic layer was washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The obtained residue was purified by silica-gel column chromatography (chloroform), and the title compound (134 mg (yield >99%)) was obtained as a yellow crystal.

Provenance & Evidence