反应详情

Under an argon atmosphere, (2R,5S)-tert-butyl 4-benzyl-2,5-dimethylpiperazine-1-carboxylate (2.0 g, 6.57 mmol) was dissolved in methanol (60 mL), and added 10% palladium carbon (670 mg) and formic acid (1.5 g, 32.9 mmol). The mixture was stirred at room temperature for 2 hours. Then, the reaction solution was filtered through a pad of celite, and concentrated in vacuo. The obtained residue was added chloroform and a saturated aqueous solution of sodium hydrogen carbonate, extracted with chloroform, dried over sodium sulfate, concentrated in vacuo, and the title compound (1.56 g, >100%) was obtained as a yellow oil.

1. filtrationThen, the reaction solution was filtered through a pad of celite
2. concentrationconcentrated in vacuo
3. additionThe obtained residue was added chloroform
4. extractiona saturated aqueous solution of sodium hydrogen carbonate, extracted with chloroform
5. dry with materialdried over sodium sulfate
6. concentrationconcentrated in vacuo