5-[5-(1-Methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dione → 3-(2-[(R)-4-{4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyl}-2-methylpiperazin-1-yl]-2-oxoethyl)-5-[5-(1-methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dione

Participants

Reaction Steps

(R)-2-bromo-1-(4-{4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl]-2-propylphenyl}-2-methylpiperazin-1-yl)ethanone and 5-[5-(1-methylethoxy)pyridin-2-yl]-5-methylimidazolidine-2,4-dione were used for a similar reaction and treatment as Examples 14-1 and 15-1, and the title compound was obtained as a yellow oil.

Provenance & Evidence