5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dione → 5-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-(2-{4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyl]-1,4-diazepan-1-yl}-2-oxoethyl)-5-methylimidazolidine-2,4-dione

HRID 1038574Notes

Reaction equation

HRID 1038574 reaction equation
Br[CH2:2][C:3]([N:5]1[CH2:11][CH2:10][CH2:9][N:8]([C:12]2[CH:17]=[CH:16][C:15]([C:18]([O:27]COC)([C:23]([F:26])([F:25])[F:24])[C:19]([F:22])([F:21])[F:20])=[CH:14][C:13]=2[CH2:31][CH2:32][CH3:33])[CH2:7][CH2:6]1)=[O:4].[O:34]1[CH2:39][CH2:38][O:37][C:36]2[CH:40]=[C:41]([C:44]3([CH3:51])[NH:48][C:47](=[O:49])[NH:46][C:45]3=[O:50])[CH:42]=[CH:43][C:35]1=2>>[O:34]1[CH2:39][CH2:38][O:37][C:36]2[CH:40]=[C:41]([C:44]3([CH3:51])[NH:48][C:47](=[O:49])[N:46]([CH2:2][C:3]([N:5]4[CH2:11][CH2:10][CH2:9][N:8]([C:12]5[CH:17]=[CH:16][C:15]([C:18]([OH:27])([C:23]([F:25])([F:26])[F:24])[C:19]([F:21])([F:22])[F:20])=[CH:14][C:13]=5[CH2:31][CH2:32][CH3:33])[CH2:7][CH2:6]4)=[O:4])[C:45]3=[O:50])[CH:42]=[CH:43][C:35]1=2

Participants

3

Reactant 2

HCID 32951335-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dioneHCID 866472082-Bromo-1-(4-{4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl]-2-propylphenyl}-1,4-diazepan-1-yl)ethanone

Product 1

HCID 595639455-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-3-(2-{4-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)-2-propylphenyl]-1,4-diazepan-1-yl}-2-oxoethyl)-5-methylimidazolidine-2,4-dione

Procedure

2-Bromo-1-(4-{4-[1,1,1,3,3,3-hexafluoro-2-(methoxymethoxy)propan-2-yl]-2-propylphenyl}-1,4-diazepan-1-yl)ethanone and 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione were used for a similar reaction and treatment as Examples 14-1 and 15-1, and the title compound was obtained as a yellow oil.

Sources & evidence

ORD record
ord-fdf4c26b947b4ca39787841512b34aeb
Source dataset
uspto-grants-2013_10
Patent number
US08551985B2

Reaction notes

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