HCID 66597864, compound → 3-[2-((S)-4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-3-methylpiperazin-1-yl)-2-oxoethyl]-5-(2,3-dihydrobenzofuran-6-yl)-5-methylimidazolidine-2,4-dione

HRID 1038586Notes

Reaction equation

HRID 1038586 reaction equation
[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][N:27]([C:30](=[O:33])[CH2:31]Br)[CH2:26][C@@H:25]2[CH3:34])=[C:20]([CH:35]=[CH:36][CH3:37])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:38]1[C:42]2[CH:43]=[C:44]([C:47]3([CH3:54])[NH:51][C:50](=[O:52])[NH:49][C:48]3=[O:53])[CH:45]=[CH:46][C:41]=2[CH2:40][CH2:39]1>>[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][N:27]([C:30](=[O:33])[CH2:31][N:49]3[C:48](=[O:53])[C:47]([C:44]4[CH:45]=[CH:46][C:41]5[CH2:40][CH2:39][O:38][C:42]=5[CH:43]=4)([CH3:54])[NH:51][C:50]3=[O:52])[CH2:26][C@@H:25]2[CH3:34])=[C:20]([CH:35]=[CH:36][CH3:37])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 66597864HCID 66597864, compoundHCID 86647212HCID 86647212, compound

Product 1

HCID 866472113-[2-((S)-4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-3-methylpiperazin-1-yl)-2-oxoethyl]-5-(2,3-dihydrobenzofuran-6-yl)-5-methylimidazolidine-2,4-dione

Procedure

(S)-1-(4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-3-methylpiperazin-1-yl)-2-bromoethanone and 5-(2,3-dihydrobenzofuran-6-yl)-5-methylimidazolidine-2,4-dione were used for a similar reaction and treatment as Example 14-1, and the title compound was obtained as a yellow oil.

Sources & evidence

ORD record
ord-ebfa80ae2a9a4fc7bcfe3bfb5b8b0c2f
Source dataset
uspto-grants-2013_10
Patent number
US08551985B2

Reaction notes

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