HCID 66597864, compound → HCID 86647213, compound

HRID 1038587Notes

Reaction equation

[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][N:27]([C:30](=[O:33])[CH2:31]Br)[CH2:26][C@@H:25]2[CH3:34])=[C:20]([CH:35]=[CH:36][CH3:37])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O1C2C=C(C3(C)NC(=O)NC3=O)C=CC=2CC1.[O:55]1[C:64]2[C:59](=[N:60][CH:61]=[C:62]([C:65]3([CH3:72])[NH:69][C:68](=[O:70])[NH:67][C:66]3=[O:71])[CH:63]=2)[O:58][CH2:57][CH2:56]1>>[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH2:29][CH2:28][N:27]([C:30](=[O:33])[CH2:31][N:67]3[C:66](=[O:71])[C:65]([C:62]4[CH:63]=[C:64]5[O:55][CH2:56][CH2:57][O:58][C:59]5=[N:60][CH:61]=4)([CH3:72])[NH:69][C:68]3=[O:70])[CH2:26][C@@H:25]2[CH3:34])=[C:20]([CH:35]=[CH:36][CH3:37])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 3

HCID 66597864HCID 66597864, compound

HCID 66598752HCID 66598752, compound

HCID 86647212HCID 86647212, compound

Product 1

HCID 86647213HCID 86647213, compound

Procedure

(S)-1-(4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-3-methylpiperazin-1-yl)-2-bromoethanone, 5-(2,3-dihydrobenzofuran-6-yl)-5-methylimidazolidine-2,4-dione and 5-(2,3-dihydro-[1,4]dioxino[2,3-b]pyridin-7-yl)-5-methylimidazolidine-2,4-dione were used for a similar reaction and treatment as Example 14-1, and the title compound was obtained as a yellow oil.

Sources & evidence

ORD record: ord-d49c94219c9541b79529810126275c45
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08551985B2

Reaction notes

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