Hydrogen Peroxide → 5-(methoxymethoxy)-2-methylpyridin-4(1H)-one

Participants

Reaction Steps

To a solution of 5-(methoxymethoxy)-2-methylpyridin-4-ylboronic acid (500 mg, 2.54 mmol) in tetrahydrofuran (12.7 mL), an aqueous solution of hydrogen peroxide (purity 30%) (2.9 mL, 25.4 mmol) was added at room temperature, and the mixture was stirred at room temperature for 4 hours. The reaction solution was added a saturated aqueous solution of sodium persulfate, and concentrated in vacuo. The obtained residue was washed and filtered with chloroform/methanol, and the title compound (440 mg (yield >100%)) was obtained as a yellow amorphous.

Provenance & Evidence