反应详情

温度

60 °C

2-(Hydroxymethyl)-5-[(4-methoxybenzyl)oxy]pyridin-4(1H)-one (3.21 g, 12.2 mmol) was dissolved in pyridine (60 mL), added acetyl chloride (1.44 g, 18.3 mmol) under ice-cold conditions, and the mixture was stirred at 60° C. overnight. Then, the reaction solution was concentrated in vacuo. Water was added under ice-cold conditions, and stirred at room temperature for 30 minutes. The deposited solid was filtered, washed with iced water and diethyl ether, concentrated in vacuo, and the title compound (3.56 g (yield 96%)) was obtained as brown powder crystal.

1. concentrationThen, the reaction solution was concentrated in vacuo
2. additionWater was added under ice-cold conditions
3. stirringstirred at room temperature for 30 minutes
4. filtrationThe deposited solid was filtered
5. washwashed with iced water and diethyl ether
6. concentrationconcentrated in vacuo