HRID1038610

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CC1(c2ccc3c(c2)OCCO3)NC(=O)NC1=O

HCID3295133

未命名化合物

反应SMILES：CC=Cc1cc(C(OCc2ccccc2)(C(F)(F)F)C(F)(F)F)ccc1N1C[C@H](C)N(C(=O)CBr)C[C@H]1C

HCID86647217

未命名化合物

PRODUCTS

产物

$反应SMILES：C/C=C\c1cc(C(OCc2ccccc2)(C(F)(F)F)C(F)(F)F)ccc1N1C[C@@H](C)N(C(=O)CN2C(=O)N[C@@](C)(c3ccc4c(c3)OCCO4)C2=O)CC1C$

HCID86647216

未命名化合物

PROCEDURE

实验过程

1-((2S,5R)-4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl) phenyl}-2,5-dimethylpiperazin-1-yl)-2-bromoethanone and 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione were used for a similar reaction and treatment as Example 14-1, and the title compound was obtained as a yellow oil.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-2de73cb8b7a24f60b02ed0767244fa74
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08551985B2
来源说明: uspto-grants-2013_10

反应SMILES

[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[C@H:29]([CH3:30])[CH2:28][N:27]([C:31](=[O:34])[CH2:32]Br)[C@@H:26]([CH3:35])[CH2:25]2)=[C:20]([CH:36]=[CH:37][CH3:38])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:39]1[CH2:44][CH2:43][O:42][C:41]2[CH:45]=[C:46]([C:49]3([CH3:56])[NH:53][C:52](=[O:54])[NH:51][C:50]3=[O:55])[CH:47]=[CH:48][C:40]1=2>>[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH:29]([CH3:30])[CH2:28][N:27]([C:31](=[O:34])[CH2:32][N:51]3[C:50](=[O:55])[C@@:49]([C:46]4[CH:47]=[CH:48][C:40]5[O:39][CH2:44][CH2:43][O:42][C:41]=5[CH:45]=4)([CH3:56])[NH:53][C:52]3=[O:54])[C@H:26]([CH3:35])[CH2:25]2)=[C:20](/[CH:36]=[CH:37]\[CH3:38])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1