5-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dione → (2R,5S,Z)-3-[2-(4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-2,5-dimethylpiperazin-1-yl)-2-oxoethyl]-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione

HRID 1038610Notes

Reaction equation

HRID 1038610 reaction equation
[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[C@H:29]([CH3:30])[CH2:28][N:27]([C:31](=[O:34])[CH2:32]Br)[C@@H:26]([CH3:35])[CH2:25]2)=[C:20]([CH:36]=[CH:37][CH3:38])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[O:39]1[CH2:44][CH2:43][O:42][C:41]2[CH:45]=[C:46]([C:49]3([CH3:56])[NH:53][C:52](=[O:54])[NH:51][C:50]3=[O:55])[CH:47]=[CH:48][C:40]1=2>>[CH2:1]([O:8][C:9]([C:18]1[CH:23]=[CH:22][C:21]([N:24]2[CH:29]([CH3:30])[CH2:28][N:27]([C:31](=[O:34])[CH2:32][N:51]3[C:50](=[O:55])[C@@:49]([C:46]4[CH:47]=[CH:48][C:40]5[O:39][CH2:44][CH2:43][O:42][C:41]=5[CH:45]=4)([CH3:56])[NH:53][C:52]3=[O:54])[C@H:26]([CH3:35])[CH2:25]2)=[C:20](/[CH:36]=[CH:37]\[CH3:38])[CH:19]=1)([C:14]([F:17])([F:16])[F:15])[C:10]([F:13])([F:12])[F:11])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 32951335-(2,3-Dihydro-1,4-benzodioxin-6-yl)-5-methylimidazolidine-2,4-dioneHCID 866472171-((2S,5R)-4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl) phenyl}-2,5-dimethylpiperazin-1-yl)-2-bromoethanone

Product 1

HCID 86647216(2R,5S,Z)-3-[2-(4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl)phenyl}-2,5-dimethylpiperazin-1-yl)-2-oxoethyl]-5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione

Procedure

1-((2S,5R)-4-{4-[2-(benzyloxy)-1,1,1,3,3,3-hexafluoropropan-2-yl]-2-(prop-1-en-1-yl) phenyl}-2,5-dimethylpiperazin-1-yl)-2-bromoethanone and 5-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)-5-methylimidazolidine-2,4-dione were used for a similar reaction and treatment as Example 14-1, and the title compound was obtained as a yellow oil.

Sources & evidence

ORD record
ord-2de73cb8b7a24f60b02ed0767244fa74
Source dataset
uspto-grants-2013_10
Patent number
US08551985B2

Reaction notes

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