1,3-Dichloro-2-isocyanatobenzene → 1-(2,6-Dichloro-phenyl)-3-[6-(4-diethylamino-phenylamino)-pyrimidin-4-yl]-urea

HRID 1038673Notes

Reaction equation

HRID 1038673 reaction equation
[CH2:1]([N:3]([CH2:18][CH3:19])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][C:11]2[CH:16]=[C:15]([NH2:17])[N:14]=[CH:13][N:12]=2)=[CH:6][CH:5]=1)[CH3:2].[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:22]=1[N:28]=[C:29]=[O:30]>>[Cl:20][C:21]1[CH:26]=[CH:25][CH:24]=[C:23]([Cl:27])[C:22]=1[NH:28][C:29]([NH:17][C:15]1[CH:16]=[C:11]([NH:10][C:7]2[CH:6]=[CH:5][C:4]([N:3]([CH2:1][CH3:2])[CH2:18][CH3:19])=[CH:9][CH:8]=2)[N:12]=[CH:13][N:14]=1)=[O:30]

Participants

3

Reactant 2

HCID 6045371,3-Dichloro-2-isocyanatobenzeneHCID 66669959N-(4-Diethylamino-phenyl)-pyrimidine-4,6-diamine

Product 1

HCID 577102221-(2,6-Dichloro-phenyl)-3-[6-(4-diethylamino-phenylamino)-pyrimidin-4-yl]-urea

Procedure

The title compound is prepared analogously as described in Example 105A from N-(4-diethylamino-phenyl)-pyrimidine-4,6-diamine and 2,6-dichlorophenyl isocyanate.

Sources & evidence

ORD record
ord-c4a1ee3d9c4f467f94e55e1ed874e266
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

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