Diethyl Ether → HCID 57710300, compound

Participants

Reaction Steps

To a freshly prepared solution of methylmagnesium iodide in diethyl ether (8 mL, ˜7 mmol) is added 1-[6-(4-acetyl-phenylamino)-pyrimidin-4-yl]-3-(2,6-dichloro-phenyl)-1-methyl-urea (0.5 g, 1.16 mmol) in several portions. After stirring for 5 h, THF (4 mL) is added. After 16 h the reaction is quenched by the addition of H2O and CH3OH and evaporated in vacuo. The residue is co-evaporated twice with toluene and purified by flash chromatography (CH2Cl2/CH3OH). The combined pure fractions are evaporated to afford the title compound.

Provenance & Evidence