Ethanol → N4-Methyl-N6-[3-(trifluoromethyl)phenyl]-4,6-pyrimidinediamine

Participants

Reaction Conditions

Reaction Steps

A solution of methylamine in ethanol (32 mL, 256 mmol) is added to (6-chloro-pyrimidin-4-yl)-(3-trifluoromethyl-phenyl)-amine (3.49 g, 12.8 mmol) and the mixture is stirred for 5 h at 100° C. in a pressure bottle. The reaction mixture is concentrated in vacuo, the residue diluted with CH3OH and basified using conc. aqueous ammonia solution. The product is filtered off, washed with H2O and CH3OH and dried in vacuo.

Provenance & Evidence