4-Fluoroaniline → N-(4-Fluoro-phenyl)-pyrimidine-4,6-diamine

HRID 1038688Notes

Reaction equation

Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[F:9][C:10]1[CH:16]=[CH:15][C:13]([NH2:14])=[CH:12][CH:11]=1>>[F:9][C:10]1[CH:16]=[CH:15][C:13]([NH:14][C:2]2[CH:3]=[C:4]([NH2:8])[N:5]=[CH:6][N:7]=2)=[CH:12][CH:11]=1

Participants

Reactant 2

HCID 97314-Fluoroaniline

HCID 2380124-Amino-6-chloropyrimidine

Product 1

HCID 66669888N-(4-Fluoro-phenyl)-pyrimidine-4,6-diamine

Procedure

The title compound is prepared analogously as described in Example 114A from 6-chloro-pyrimidin-4-ylamine and 4-fluoroaniline.

Sources & evidence

ORD record: ord-583d514b9468412ba3e055527c251bcd
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08552002B2

Reaction notes

Loading…