5-Isocyanato-1,2,3-trimethoxybenzene → 1-[6-(3-Chloro-phenylamino)-pyrimidin-4-yl]-3-(3,4,5-trimethoxy-phenyl)-urea

HRID 1038707Notes

Reaction equation

HRID 1038707 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[CH:14]=[C:13]([NH2:15])[N:12]=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH3:16][O:17][C:18]1[CH:19]=[C:20]([N:28]=[C:29]=[O:30])[CH:21]=[C:22]([O:26][CH3:27])[C:23]=1[O:24][CH3:25]>>[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:10]=[CH:11][N:12]=[C:13]([NH:15][C:29]([NH:28][C:20]3[CH:19]=[C:18]([O:17][CH3:16])[C:23]([O:24][CH3:25])=[C:22]([O:26][CH3:27])[CH:21]=3)=[O:30])[CH:14]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5177665-Isocyanato-1,2,3-trimethoxybenzeneHCID 66669982N~4~-(3-chlorophenyl)pyrimidine-4,6-diamine

Product 1

HCID 577104271-[6-(3-Chloro-phenylamino)-pyrimidin-4-yl]-3-(3,4,5-trimethoxy-phenyl)-urea

Procedure

The title compound is prepared analogously as described in Example 127 from N-(3-chloro-phenyl)-pyrimidine-4,6-diamine and 3,4,5-trimethoxyphenyl isocyanate.

Sources & evidence

ORD record
ord-eac548e3ccf64e398072bb75d3955d75
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

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