反应详情

Ethylamine (70% in water, 16 ml, 45.08 mmol, 2.5 eq.) is added dropwise (15 min) to a suspension of 4,6-dichloropyrimidine (12 g, 80.5 mmol) in EtOH (36 ml) at RT. The resulting yellowish solution is allowed to stir for 1 h at RT and then cooled to 0° C. The resulting white precipitate is collected by vacuum filtration, washed with water and dried in vacuo to afford 12.4 g of the title compound: ESI-MS: 157.9 [MH]+; single peak at tR=2.02 min (purity: 100%, gradient J).

1. temperaturecooled to 0° C
2. filtrationThe resulting white precipitate is collected by vacuum filtration
3. washwashed with water
4. customdried in vacuo