HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Ethyl-4-(4-nitrobenzyl)piperazine → 4-[(4-Ethylpiperazin-1-yl)methyl]aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Ethyl-4-(4-nitrobenzyl)piperazine | HCID 792557 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[(4-Ethylpiperazin-1-yl)methyl]aniline | HCID 1084996 | 98.6% |
Reaction Steps
A suspension of 1-ethyl-4-(4-nitro-benzyl)-piperazine (7.2 g, 29.14 mmol) and Raney Nickel (1.5 g) in MeOH (100 mL) is stirred for 6 h at RT, under a hydrogen atmosphere. The reaction mixture is filtered through a pad of celite and concentrated to afford 6.3 g of the title compound as a yellow solid: ESI-MS: 220.1 [MH]+; TLC: Rf=0.08 (DCM/MeOH+1% NH3aq, 9:1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552002B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-c7699ef0cdbe4ad5ada378418fe2b3c0 |
| Source note | uspto-grants-2013_10 |