4-Amino-6-chloropyrimidine → HCID 66669941, compound

HRID 1038723Notes

Reaction equation

HRID 1038723 reaction equation
Cl[C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH2:8])[CH:3]=1.[N:9]1([CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1>>[N:9]1([CH2:14][CH2:15][O:16][C:17]2[CH:18]=[CH:19][C:20]([NH:23][C:2]3[CH:3]=[C:4]([NH2:8])[N:5]=[CH:6][N:7]=3)=[CH:21][CH:22]=2)[CH2:13][CH2:12][CH2:11][CH2:10]1

Participants

3

Reactant 2

HCID 2380124-Amino-6-chloropyrimidineHCID 64937494-(2-(Pyrrolidin-1-yl)ethoxy)aniline

Product 1

HCID 66669941HCID 66669941, compound

Conditions

Temperature
150 °C

Procedure

The title compound is prepared as described in Example 152A but using 6-chloro-pyrimidin-4-ylamine, 4-(2-pyrrolidin-1-yl-ethoxy)-phenylamine (Example 148B), and stirring the reaction mixture for 2 h at 150° C.

Sources & evidence

ORD record
ord-e079231abeb442a6a4029049d093b7bc
Source dataset
uspto-grants-2013_10
Patent number
US08552002B2

Reaction notes

Loading…