4-Amino-6-chloropyrimidine → N-{4-[2-(4-Methyl-piperazin-1-yl)-ethoxy]-phenyl}-pyrimidine-4,6-diamine

Participants

Reaction Conditions

Reaction Steps

The title compound is prepared as described in Example 152A but using 4-[2-(4-methyl-piperazin-1-yl)-ethoxy]-phenylamine (300 mg, 1.28 mmol, 1 eq.), 6-chloro-pyrimidin-4-ylamine, water (0.5 ml), and stirring the reaction mixture for 2 h at 150° C. The crude product is purified by trituration in diethyl ether to afford the title compound as a white solid. ESI-MS: 329.1 [MH]+; tR=0.98 min (purity: 100%, gradient J).

Provenance & Evidence