HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1038743Generated: November 1, 2026
Phosgene → 2,6-Dichloro-3,5-dimethoxyphenyl isocyanate
https://huagongshe.com/reaction/1038743
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Phosgene | HCID 6371 | — |
| Reactant | 2,6-Dichloro-3,5-dimethoxyaniline | HCID 59486253 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2,6-Dichloro-3,5-dimethoxyphenyl isocyanate | HCID 86086993 | — |
Reaction Steps
To a solution of 2,6-dichloro-3,5-dimethoxy-aniline (133 mg, 0.60 mmol; Preparation 2) in 2 ml of dioxane under a nitrogen atmosphere, phosgene (0.54 ml 20% in toluene, 1.0 mmol) is added. The mixture is stirred for 60 min at 100° C., cooled to RT and concentrated in vacuo, yielding 2,6-dichloro-3,5-dimethoxyphenylisocyanate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08552002B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-992c1632b1ef4fa7a31ab59facac0259 |
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| Source note | uspto-grants-2013_10 |
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