4-Fluoro-3-(trifluoromethyl)phenyl isocyanate → 3-(4-Fluoro-3-trifluoromethyl-Phenyl)-1-methyl-1-{4-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-[1,3,5]triazin-2-yl}-urea

Participants

Reaction Conditions

Reaction Steps

To a solution of N-methyl-N′-[4-(4-ethyl-piperazin-1-yl)-phenyl]-[1,3,5]triazine-2,4-diamine (24 mg, 0.077 mmol) in 1.5 ml THF and 2.5 ml toluene, 4-fluoro-3-trifluoromethyl-phenyl-isocyanate (25 μl, 0.17 mmol) is added and the mixture is stirred for 5 h at 100° C. Workup analogously as described in Example 171 gives the title compound: ESI-MS: 519 [MH]+; tR=4.3 min (purity: 100%, gradient J); TLC: Rf=0.43 (DCM/MeOH 9).

Provenance & Evidence