HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,4-Dichloro-3-nitrobenzotrifluoride → 2,6-Dichloro-3-(trifluoromethyl)aniline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,4-Dichloro-3-nitrobenzotrifluoride | HCID 2736841 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2,6-Dichloro-3-(trifluoromethyl)aniline | HCID 13470473 | — |
Reaction Steps
Hydrogenation of 2,4-dichloro-3-nitro-benzotrifluoride (5.0 g, 19.2 mmol; ABCR, Karlsruhe/Germany) in 100 ml MeOH in the presence of 1 g Raney-nickel, filtration and concentration of the filtrate gives the title compound: TLC: Rf=0.67 (EE).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552002B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-abd7b1174d8943b1a8c22a4995ba8fcf |
| Source note | uspto-grants-2013_10 |