1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride → HCID 86646550, compound

Participants

Reaction Steps

[4-(5-Nitropyridin-2-yloxy)indol-1-yl]acetic acid (0.210 g, 0.670 mmol) was dissolved in a mixture of THF (10 mL)-DMF (2 mL). To the solution were added 1-benzo[1,3]dioxol-5-yl-methylpiperazine (0.148 g, 0.670 mmol), then 1-ethyl-3-(3-di-methylaminopropyl)carbodiimide hydrochloride (0.129 g, 0.670 mmol), and the resulting solution was stirred for 3 hours at room temperature. Brine (50 mL) was added to the reaction solution, and the mixture was extracted with ethyl acetate (30 mL). After the organic layer was washed with brine, then dried over anhydrous sodium sulfate, the solvent was evaporated. The obtained residue was recrystallized from ethyl acetate to yield 0.258 g of the title compound as pale brown powder.

Provenance & Evidence