Trifluoroacetic acid → HCID 68494150, compound

Participants

Reaction Steps

To 4-{1-methyl-5-[5-(4-trifluoromethylbenzoylamino)-pyridin-2-yloxy]-1H-indole-2-carbonyl}piperazine-1-carboxylic acid tert-butyl ester (2.75 g, 4.41 mmol) was added trifluoroacetic acid (16 mL) under ice cooling. The reaction mixture was stirred for 1 hour at room temperature. The reaction mixture was evaporated under reduced pressure. The residue was made alkaline with 5 M NaOH, and extracted with dichloromethane. The organic layer was washed with brine, dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure to afford 2.03 g of the title compound as a yellow amorphous powder.

Provenance & Evidence