Aniline → HCID 58938502, compound

HRID 1038919Notes

Reaction equation

HRID 1038919 reaction equation
[CH3:1][C:2]1O[C:4](=[O:12])[C:5]2[CH:11]=[N:10][CH:9]=[CH:8][C:6]=2[N:7]=1.[NH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>N1C=CC=CC=1>[CH3:1][C:2]1[N:13]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[C:4](=[O:12])[C:5]2[CH:11]=[N:10][CH:9]=[CH:8][C:6]=2[N:7]=1

Participants

4

Reactant 2

HCID 6115AnilineHCID 231513702-Methyl-4H-pyrido[4,3-d][1,3]oxazin-4-one

Product 1

HCID 58938502HCID 58938502, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Compound 17 (350 mg, 21.6 mmol) was mixed with aniline (200 mg, 21.6 mmol) in 3 mL of pyridine. The resulted solution was heated in a microwave for 25 min keeping temperature constant at 250° C. The crude material 18 was concentrated in vacuo, co-evaporated with toluene (3×10 mL), dried under vacuum for 1 h and used in the next step without further purification.

Workup

  1. temperatureThe resulted solution was heated in a microwave for 25 min
  2. customconstant at 250° C
  3. concentrationThe crude material 18 was concentrated in vacuo, co-evaporated with toluene (3×10 mL)
  4. customdried under vacuum for 1 h
  5. customused in the next step without further purification

Sources & evidence

ORD record
ord-c24b8f2e6fb442ae9e3795d2fc8a032d
Source dataset
uspto-grants-2013_10
Patent number
US08552009B2

Reaction notes

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