HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethyl orthoacetate → 3-(3,4-dichlorophenyl)-2-methylquinazolin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethyl orthoacetate | HCID 66221 | — |
| Reactant | 2-amino-N-(3,4-dichlorophenyl)benzamide | HCID 478821 | — |
| Solvent | Water | HCID 962 | — |
| Product | 3-(3,4-dichlorophenyl)-2-methylquinazolin-4-one | HCID 588867 | — |
Reaction Steps
A mixture of 62 (2.8 g, 0.009 mol) and 1,1,1-triethoxy-ethane (5.2 mL, 0.028 mol) were heated for 5 hours. The reaction mixture was poured into water, filtered, washed with water yielding compound 63 (55%). After recrystallization from EtOH, the material was used in next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552009B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-077354279ce64dbb897bd382a0150834 |
| Source note | uspto-grants-2013_10 |