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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1038968Generated: November 2, 2026

Thionyl Chloride → 4-Chloro-6,7-dimethoxyquinazoline

https://huagongshe.com/reaction/1038968

Reaction equation

Participants

RoleNameHCIDCharge
ReactantThionyl ChlorideHCID 24386—
Reactant6,7-Dimethoxy-3H-quinazolin-4-oneHCID 135495016—
SolventDimethylformamideHCID 6228—
Product4-Chloro-6,7-dimethoxyquinazolineHCID 2769364—

Reaction Steps

An analogous reaction to that described in Example 1, starting with 6,7-Dimethoxy-3H-quinazolin-4-one (31) reacted with thionylchloride in presence of DMF gave compound 32.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08552018B2
Source datasetuspto-grants-2013_10
ORD IDord-66959c20d7d24e3f9c2bfd7f99d7d9c1
Source noteuspto-grants-2013_10