3-Bromo-4-fluorobenzotrifluoride → HCID 56655539, compound

HRID 1038997Notes

Reaction equation

HRID 1038997 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:11]2=[O:20])=[CH:6][CH:5]=1.Br[C:24]1[CH:29]=[C:28]([C:30]([F:33])([F:32])[F:31])[CH:27]=[CH:26][C:25]=1[F:34]>>[F:34][C:25]1[CH:24]=[CH:29][C:28]([C:30]([F:31])([F:32])[F:33])=[CH:27][C:26]=1[N:17]1[CH2:16][CH2:15][C:12]2([C:11](=[O:20])[N:10]([C:7]3[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:21])[F:22])=[CH:5][CH:6]=3)[CH2:14][CH2:13]2)[CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 1442953-Bromo-4-fluorobenzotrifluorideHCID 667427592-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 56655539HCID 56655539, compound

Procedure

The title compound was prepared in analogy to example 1 step D from a mixture of 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 1 step C) and 2-bromo-1-fluoro-4-trifluoromethyl-benzene. Light yellow solid. MS (ESI): 477.1 (MH+)

Sources & evidence

ORD record
ord-3060e2283dd84147a130ac55936d2131
Source dataset
uspto-grants-2013_10
Patent number
US08552024B2

Reaction notes

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