1-Bromo-3-(trifluoromethoxy)benzene → 8-(3-Trifluoromethoxy-phenyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

HRID 1038999Notes

Reaction equation

HRID 1038999 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:11]2=[O:20])=[CH:6][CH:5]=1.Br[C:24]1[CH:29]=[CH:28][CH:27]=[C:26]([O:30][C:31]([F:34])([F:33])[F:32])[CH:25]=1>>[F:32][C:31]([F:33])([F:34])[O:30][C:26]1[CH:25]=[C:24]([N:17]2[CH2:16][CH2:15][C:12]3([C:11](=[O:20])[N:10]([C:7]4[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:21])[F:22])=[CH:5][CH:6]=4)[CH2:14][CH2:13]3)[CH2:19][CH2:18]2)[CH:29]=[CH:28][CH:27]=1

Participants

3

Reactant 2

HCID 5199641-Bromo-3-(trifluoromethoxy)benzeneHCID 667427592-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 566556108-(3-Trifluoromethoxy-phenyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one

Procedure

The title compound was prepared in analogy to example 1 step D from a mixture of 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 1 step C) and 1-bromo-3-trifluoromethoxy-benzene. Light yellow solid. MS (ESI): 475.1 (MH+)

Sources & evidence

ORD record
ord-115c7f9ac1d94690a3d5d5f473da2433
Source dataset
uspto-grants-2013_10
Patent number
US08552024B2

Reaction notes

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