HCID 66742100, compound → HCID 56655689, compound

HRID 1039007Notes

Reaction equation

HRID 1039007 reaction equation
[F:1][C:2]([F:22])([F:21])[O:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[CH2:14][CH2:13][C:12]3([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[C:11]2=[O:20])=[CH:6][CH:5]=1.Br[C:24]1[C:25](=[O:33])[N:26]([CH2:30][CH2:31][CH3:32])[CH:27]=[CH:28][CH:29]=1>>[O:33]=[C:25]1[C:24]([N:17]2[CH2:16][CH2:15][C:12]3([C:11](=[O:20])[N:10]([C:7]4[CH:8]=[CH:9][C:4]([O:3][C:2]([F:1])([F:21])[F:22])=[CH:5][CH:6]=4)[CH2:14][CH2:13]3)[CH2:19][CH2:18]2)=[CH:29][CH:28]=[CH:27][N:26]1[CH2:30][CH2:31][CH3:32]

Participants

3

Reactant 2

HCID 66742100HCID 66742100, compoundHCID 667427592-(4-(Trifluoromethoxy)phenyl)-2,8-diazaspiro[4.5]decan-1-one

Product 1

HCID 56655689HCID 56655689, compound

Procedure

The title compound was prepared in analogy to example 1 step D from a mixture of 2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 1 step C) and 3-bromo-1-propyl-1H-pyridin-2-one. Off-white solid. MS (ESI): 450.2 (MH+)

Sources & evidence

ORD record
ord-dd3185f3d3ac409487775d55eaf445e4
Source dataset
uspto-grants-2013_10
Patent number
US08552024B2

Reaction notes

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