HCID 56655613, compound → HCID 56655690, compound

Participants

Reaction Steps

To a solution of 8-(2-methoxy-phenyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 7, 16 mg, 0.04 mmol) in DCM (1 mL) at −78° C. was added borontribromide (1M, 110 uL, 0.12 mmol) drop wise. The reaction mixture was warmed to r.t. and stirring was continued overnight. The reaction mixture was quenched with sat. NaHCO3 and extracted with DCM. The combined organic extracts were washed with brine, dried (Na2SO4), filtered and evaporated under reduced pressure to yield the title compound a white solid (9 mg, 61%). MS (ESI): 407.4 (MH+).

Provenance & Evidence