Boron tribromide → HCID 56655691, compound

HRID 1039009Notes

Reaction equation

C[O:2][C:3]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:4]=1[N:10]1[CH2:31][CH2:30][C:13]2([C:17](=[O:18])[N:16]([C:19]3[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=3)[CH2:15][CH2:14]2)[CH2:12][CH2:11]1.B(Br)(Br)Br>>[OH:2][C:3]1[CH:8]=[CH:7][C:6]([CH3:9])=[CH:5][C:4]=1[N:10]1[CH2:31][CH2:30][C:13]2([C:17](=[O:18])[N:16]([C:19]3[CH:24]=[CH:23][C:22]([O:25][C:26]([F:28])([F:29])[F:27])=[CH:21][CH:20]=3)[CH2:15][CH2:14]2)[CH2:12][CH2:11]1

Participants

Reactant 2

HCID 25134Boron tribromide

HCID 56655614HCID 56655614, compound

Product 1

HCID 56655691HCID 56655691, compound

Procedure

The title compound was prepared in analogy to example 13 from a mixture of 8-(2-methoxy-5-methyl-phenyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one (described in example 8) and boron tribromide. Light yellow solid. MS (ESI): 421.1 (MH+)

Sources & evidence

ORD record: ord-97e5f14eac314725bbc6f53ab72b0f40
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08552024B2

Reaction notes

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