Vinyl Acetate → 2-fluoro-5-(1H-1,2,3-triazol-1-yl)pyridine

関与物質

反応条件

反応手順

5-Azido-2-fluoropyridine (262 mg, 1.9 mmol) step 1 of this example and vinyl acetate (4.0 mL, 43 mmol) were mixed in a flame dried high pressure sealable vessel. The reaction vessel was evacuated and charged with nitrogen, sealed, and heated to 100° C. for 15 hours. The reaction was cooled to room temperature and TLC indicated that the reaction was complete. Minimal dichloromethane was added to the reaction (just enough to dissolve solids that formed upon cooling) and the solution directly chromatographed on silica gel (Biotage™ size 40S column), eluting with 20-50% ethyl acetate/heptane to give the title compound as a white solid.

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