HRID1039075

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID67962197

未命名化合物

HCID86666141

未命名化合物

PRODUCTS

产物

HCID67962339

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized by procedure analogous to Step 2 and 3 of Example 28 from 2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethyl 4-methylbenzenesulfonate from Step 1 of Example 5 and tert-butyl (4-methyl-5-nitropyridin-2-yl)carbamate from Step 1 of this example.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-89de2f729d8f4eb3af18d7b0f3e93015
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US08552022B2
来源说明: uspto-grants-2013_10

反应SMILES

CC1C=CC(S(O[CH2:12][CH2:13][C@@H:14]2[CH2:16][C@@H:15]2[CH:17]2[CH2:22][CH2:21][N:20]([C:23]3[N:28]=[CH:27][C:26]([Cl:29])=[CH:25][N:24]=3)[CH2:19][CH2:18]2)(=O)=O)=CC=1.[CH3:30][C:31]1[C:36]([N+:37]([O-])=O)=[CH:35][N:34]=[C:33]([NH:40][C:41](=[O:47])[O:42][C:43]([CH3:46])([CH3:45])[CH3:44])[CH:32]=1>>[NH2:37][C:36]1[C:31]([CH3:30])=[CH:32][C:33]([N:40]([CH2:12][CH2:13][C@@H:14]2[CH2:16][C@@H:15]2[CH:17]2[CH2:18][CH2:19][N:20]([C:23]3[N:24]=[CH:25][C:26]([Cl:29])=[CH:27][N:28]=3)[CH2:21][CH2:22]2)[C:41](=[O:47])[O:42][C:43]([CH3:44])([CH3:45])[CH3:46])=[N:34][CH:35]=1