Di-tert-butyl {5-[(tert-butoxycarbonyl)amino]-3-methylpyridin-2-yl}imidodicarbonate → N-(2-{(1S,2S)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethyl)-3-methylpyridine-2,5-diamine

Participants

Reaction Steps

The title compound was synthesized by procedure analogous to Step 2 of Example 11 from 2-{(1S,2R)-2-[1-(5-chloropyrimidin-2-yl)piperidin-4-yl]cyclopropyl}ethyl 4-methylbenzenesulfonate from Step 1 of Example 5 and di-tert-butyl {5-[(tert-butoxycarbonyl)amino]-3-methylpyridin-2-yl}imidodicarbonate from Step 2 of this example.

Provenance & Evidence