1,2-Dichloroethane → HCID 67962335, compound

Participants

Reaction Steps

{4-[(tert-butoxycarbonyl)amino]phenyl}acetic acid (300 mg, 1.2 mmol) was dissolved in DMF (3 ml). EDC (275 mg, 1.4 mmol), HOBt (256 mg, 1.7 mmol), DIEA (450 mg, 3.6 mmol) and cyclopropyl amine (82 mg, 1.4) were added and the mixture stirred at RT for 2 hours. The mixture was diluted into a 10% solution of sodium bicarbonate (aq, 50 ml), extracted with EtOAc (3×30 ml), the organic fractions combined, dried over Na2SO4, filtered and the volatiles removed in vacuum to give the titled compound. LRMS calc: 290.16; obs: 397.27 (M+1).

Provenance & Evidence