2,2-Dimethyl-N-(5-nitro-2-pyridinyl)propanamide → N-(5-Aminopyridin-2-yl)-2,2-dimethylpropanamide

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Reaction Steps

2,2-dimethyl-N-(5-nitropyridin-2-yl)propanamide (300 mg, 1.34 mmol) from Step 1 of this example was dissolved with stirring in MeOH (4.5 ml). Palladium on carbon (10%, 75 mg) was added and the slurry degassed, placed under an atmosphere of hydrogen (3×) and stirred at RT for 30 minutes. The mixture was filtered through CELITE, the filter cake washed with EtOAc (3×100 ml), the filtrates combined and the volatiles removed in vacuum to give the titled compound.

Provenance & Evidence