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HRID 1039124作成日：2026年10月25日
Methyl 2-isothiocyanatoacetate → Methyl 2-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]-ethylidene}-hydrazinocarbonothioyl)amino]acetate
https://huagongshe.com/reaction/1039124
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Methyl 2-isothiocyanatoacetate | HCID 140795 | — |
| 反応物 | Methanol--water (1/1) | HCID 22242641 | — |
| 反応物 | 2-(3,4-Dichlorophenyl)-4-(1-hydrazinylideneethyl)thiophene-3-ol | HCID 71405258 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | Methyl 2-[(2-{1-[5-(3,4-dichlorophenyl)-4-hydroxythiophen-3-yl]-ethylidene}-hydrazinocarbonothioyl)amino]acetate | HCID 72989195 | 0.72% |
反応手順
A solution of 2-(3,4-dichlorophenyl)-4-(1-hydrazonoethyl)thiophen-3-ol (30 mg, 0.10 mmol) prepared in Reference Synthetic Example 1 and methyl 2-isothiocyanatoacetate (20 mg, 0.15 mmol) in dimethyl formamide (300 μL) was stirred at room temperature, 40° C. and 50° C. for 2 hours, respectively. After addition of methanol-water, the solution was stirred at room temperature for 0.5 hour, and the resulting crystals were collected by filtration as the desired product (yield 0.72%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 特許番号 | US08552031B2 |
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| 出典データセット | uspto-grants-2013_10 |
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| ORD ID | ord-174b428f226c401d8f06bcc59d88b3b8 |
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| 出典メモ | uspto-grants-2013_10 |
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