HCID 86635889, compound → HCID 73005320, compound

HRID 1039127Notes

Reaction equation

HRID 1039127 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][CH:11]=[C:10]([C:13](=[N:15][NH:16][C:17]([N:19]3[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][C:27]([O:29]C)=[O:28])[CH2:21][CH2:20]3)=[S:18])[CH3:14])[C:9]=2[OH:31])=[CH:4][CH:3]=1>C(O)C>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:12][CH:11]=[C:10]([C:13](=[N:15][NH:16][C:17]([N:19]3[CH2:24][CH2:23][N:22]([CH2:25][CH2:26][C:27]([OH:29])=[O:28])[CH2:21][CH2:20]3)=[S:18])[CH3:14])[C:9]=2[OH:31])=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 86635889HCID 86635889, compound

Product 1

HCID 73005320HCID 73005320, compoundYield 55%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The hydrolysis procedure in Synthetic Example 2 was followed using methyl 3-[4-{1-[5-(4-bromophenyl)-4-hydroxythiophen-3-yl]-ethylidene-hydrazinothiocarbonyl}-piperazin-1-yl]propionate and ethanol as the solvent to give the desired product (yield 55%).

Workup

  1. customThe hydrolysis procedure in Synthetic Example 2

Sources & evidence

ORD record
ord-9dc926100e3f404293df576974b82bc4
Source dataset
uspto-grants-2013_10
Patent number
US08552031B2

Reaction notes

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