反应详情

Add a solution of thiobenzoylsulfanylacetic acid methyl ester (1.9 g, 8.4 mmol) in ethanol (30 mL) to a solution of anhydrous hydrazine (1 mL) at room temperature under nitrogen and stir for 2 hours. Then add water (20 mL) and remove the solvent under reduced pressure. Dissolve the residue in ethyl acetate (300 mL), wash with water (200 mL) and brine (200 mL), and dry over magnesium sulfate. Remove the solvent under reduced pressure to provide thiobenzoic acid hydrazide (1.2 g, 94%).

1. customThen add water (20 mL) and remove the solvent under reduced pressure
2. dissolutionDissolve the residue in ethyl acetate (300 mL)
3. washwash with water (200 mL) and brine (200 mL)
4. dry with materialdry over magnesium sulfate
5. customRemove the solvent under reduced pressure