HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-[5-(2-Acetylamino-phenyl)-isoxazol-3-yl]-pentanoic acid ethyl ester → 5-[5-(2-Acetylamino-phenyl)-isoxazol-3-yl]-pentanoic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-[5-(2-Acetylamino-phenyl)-isoxazol-3-yl]-pentanoic acid ethyl ester | HCID 59167770 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Product | 5-[5-(2-Acetylamino-phenyl)-isoxazol-3-yl]-pentanoic acid | HCID 68492638 | 96% |
Reaction Steps
Add 2N HCl solution (100 mL, in water) to 5-[5-(2-acetylamino-phenyl)-isoxazol-3-yl]-pentanoic acid ethyl ester (4.02 g, 12.2 mmol) and heat to reflux under N2 overnight Cool to room temperature and concentrate to afford the title compound (3.46 g, 96% yield). MS (IS) 259 (M−1)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08552039B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-1c39f945349547628df139c1db132fe6 |
| Source note | uspto-grants-2013_10 |